The Wilkinson Lab studies sensory plasticity. Muscles contain neurons which sense muscle length and movement and are the main contributors to the sense of body position and movement, or proprioception. Alterations to these sensory neurons can lead to movement and balance problems. Our lab is interested in understanding how these neurons transduce muscle stretch into action potentials and what causes these neurons to malfunction. To learn more about our research, check out our latest papers:
L.S. Elahi, K.N. Shamai, A. M. Abtahie, A.M. Cai, S. Padmanabhan, M. Bremer, K.A. Wilkinson. (2018) Diet induced obesity alters muscle spindle afferent function in adult mice. PLoS ONE 13(5): e0196832. https://doi.org/10.1371/journal.pone.0196832
S-H. Woo, V. Lukacs, J.C. de Nooij, D. Zaytseva, C.R. Criddle, A. Francisco, T.M. Jessell, K.A. Wilkinson, A. Patapoutian (2015) Piezo2 is the principal mechanotransduction channel for proprioception. Nat. Neurosci. (18), 1756-1762. Chosen as cover article.
J.A. Franco, H.E. Kloefkorn, S. Hochman, K.A. Wilkinson (2014) An In Vitro Adult Mouse Muscle-nerve Preparation for Studying the Firing Properties of Muscle Afferents. J. Vis. Exp. (91), e51948, doi:10.3791/51948.